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Mounting evidence suggests that vitamin D may prime the body's natural defences against COVID-19

A growing body of evidence suggests that vitamin D may be one of the cheapest and safest ways of tackling COVID-19.

A randomised control trial carried out at the Reina Sofía University Hospital in Spain in May and June found that treating COVID-19 patients with high dosages of vitamin D could prevent them from having to receive intensive care. Of 70 Covid-19 hospitalised patients tracked in the study, just one (2%) of the group treated additionally with vitamin D required admission to ICU, while half of the untreated patients needed to be taken into ICU, and two died. Of the patients treated with vitamin D, none died and all were discharged without complications.

In an article in the Daily Telegraph, British MP and former cabinet minister David Davis called the results "astonishing" and called on the UK government to "act now".

Why do we need vitamin D?

Vitamin D is essential for regulating calcium and phosphorus metabolism, both considered important for bone health.

Severe deficiency can result in rickets in children, and osteomalacia in adults. Low levels are also associated with chronic diseases such as rheumatoid arthritis, multiple sclerosis, cardiovascular disease and diabetes — although it is unknown whether deficiency actually contributes to causing such conditions.

It is also thought that vitamin D deficiency might be associated with sub-optimal immune function and increased risk of infection.

Researchers at the University of Edinburgh reported insights into how vitamin D regulates the immune system and may influence susceptibility to autoimmunity disease.1

The study investigated how vitamin D affects the ability of dendritic cells (a type of guard to the immune system) to activate T cells, which are important for fighting infection. In people with autoimmune disease, T cells mistakenly start to attack the body’s own tissues.

The study revealed that vitamin D caused dendritic cells to produce more of a molecule called CD31 on their surface and that this hindered the activation of T cells. CD31 also prevented dendritic and T cells from making a stable contact, which is essential for T cell activation, resulting in a “far reduced” immune reaction.

Where can I get vitamin D?

You can supplement with vitamin D, but it’s best to consult a GP or nutritional therapist before doing so. You may also find that the shops are currently empty, which is why it’s good to look to nutrition first.

Dietary sources of vitamin D include oily fish (e.g tuna, mackerel, salmon and sardines), red meat, egg yolks, liver and some fortified foods (e.g nut milks, spreads and breakfast cereals).

Exposure to sunshine is another source. Studies have shown that in the UK, nine to 13 minutes of midday sunlight exposure during summer three times per week is enough to maintain healthy levels among Caucasian adults.2

According to the NHS, people at risk of vitamin D deficiency include those who stay indoors or cover up when in the sun, minimising exposure to sunshine. It also states: “People with dark skin, from Africa, African-Caribbean and South Asian backgrounds, may also not get enough vitamin D from sunlight in the summer. They should consider taking a supplement all year round."  

Magnesium and vitamin D

A randomised trial involving 250 people has found that magnesium appears to optimise and regulate vitamin D levels.3

Researchers were interested in the role of magnesium after it was observed that people synthesise vitamin D differently, with levels not rising in some people even after being given a high dose. Lead author Qi Dai, MD, PhD, Ingram Professor of Cancer Research, said that magnesium deficiency “shuts down” the pathway for vitamin D to be synthesised and metabolised.

A separate review also concluded that vitamin D needs magnesium to be metabolised; otherwise it remains stored and inactive.4

Magnesium can be supplemented by adding Epsom salts to a hot bath. Dietary sources include green leafy vegetables, nuts, brown rice, bread, fish, meat and dairy foods.

For a full update on the link between vitamin D deficiency and COVID-19 mortality rates, subscribe to Optimum Nutrition magazine, available in digitally and in print and read summer 2020.


References:

  1. https://www.frontiersin.org/articles/10.3389/fimmu.2019.00600/full
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946282/
  3. https://www.sciencedaily.com/releases/2018/12/181214093837.htm
  4. https://jaoa.org/article.aspx?articleid=2673882